These molecules made the companies billion dollar worth…

Rank: 1

Trade Name: Lipitor 



INN: Atrovastatin

Company: Pfizer 

Technology: Chiral Chemistry 

Therapeutic Use: Cholesterol Lowering 


Sales : $125 Billion

Patent Expired : Novemeber 30, 2011

Rank 2

Trade Name: Plavix 

INN: Clopidogrel

Company: Sanofi/ Bristol 

Technology: Small Molecule Chemistry

Theraputic use: Anticlotting

Sales: $19.5 Billion, Patent Expiry: 2012

Rank 3

Trade Name: Advair

Company: Glaxo Smith Kine

Technology: Small Molecule Chemistry

Therapeutic Use: Asthma

Sales: $9.0 Billion


Patent Expiry: 2013 (European)

Rank 4

Trade Name:  Remicade


INN: Infliximab

Company: Merck,J&J

Technology: Monoclonal Antibody

Therapeutic Use: Arthritis

 Sales: $7.67 Billion, Patent Expiry: 2015

Rank: 5

Trade Name: Enbrel

Company: Pfizer (Wyeth)

Technology: Recombinant Gene Product

Therapeutic Use: Arthritis 

Sales: $7.1 Billion


Patent Expiry: 2012

Rank: 6

Trade Name: Humira

Company: Abbott

Technology: Monoclonal Antibody

Therapeutic Use: Arthritis

 Sales: $6.8 Billion

Patent Expiry: 2016

Rank 7

Trade Name: Avastin

Company: Roche

Technology: Monoclonal Antibody

Therapeutic Use: Cancer

Sales: $6.7 Billion

Rank 8

Trade Name: Rituxan

Company: Roche

Technology: Monoclonal Antibody

Therapeutic Use: Cancer

Sales: $6.1 Billion 

Rank 9

Trade Name: Diovan

Company: Novartis

Technology: Small Molecule Chemistry

Therapeutic Use: Hypertension

Sales: $ 6.0 Billion

Rank:10

Trade Name: Crestor

Company: Astrazeneca

Technology: Small Molecule Chemistry

Therapeutic Use: Cholesterol Lowering

Sales: $5.8 Billion

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