p53 Structure and Function – Cell Cycle Regualtion & Apoptosis


P53 is a tumor
suppressor gene, present in eukaryotic cell. Protein encoded by p53 regulates
cell cycle and function as tumor suppression, hence it is also known as TP53 or
tumor protein.
p53 is referred to
as “the guardian of the genome”, as its role in conserving stability by preventing
genome mutation. “53” denotes molecular mass of p53 as it runs as 53KDa band on
SDS – PAGE.

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