These molecules made the companies billion dollar worth... Rank: 1 Trade Name: Lipitor INN: Atrovastatin Company: Pfizer Technology: Chiral Chemistry Therapeutic Use: Cholesterol Lowering Sales : $125 Billion Patent Expired : Novemeber 30, 2011 Rank 2 Trade Name: Plavix INN: Clopidogrel Company: Sanofi/ Bristol Technology: Small Molecule Chemistry Theraputic use: Anticlotting Sales: $19.5 Billion, Patent Expiry: 2012 Rank 3 Trade Name: Advair Company: Glaxo Smith Kine Technology: Small Molecule Chemistry Therapeutic Use: Asthma Sales: $9.0 Billion Patent Expiry: 2013 (European) Rank 4 Trade Name: Remicade INN: Infliximab Company: Merck,J&J Technology: Monoclonal Antibody Therapeutic Use: Arthritis Sales: $7.67 Billion, Patent Expiry: 2015 Rank: 5 Trade Name: Enbrel Company: Pfizer (Wyeth) Technology: Recombinant Gene Product Therapeutic Use: Arthritis Sales: $7.1 Billion Patent Expiry: 2012 Rank: 6 Trade Name: Humira Company: Abbott Technology: Monoclonal Antibody Therapeutic Use: Arthritis Sales: $6.8 Billion Patent Expiry: 2016 Rank 7 Trade Name: Avastin Company: Roche Technology: Monoclonal Antibody Therapeutic Use: Cancer Sales: $6.7 Billion Rank 8 Trade Name: Rituxan Company: Roche Technology: Monoclonal Antibody Therapeutic Use: Cancer Sales: $6.1 Billion Rank 9 Trade Name: Diovan Company: Novartis Technology: Small Molecule Chemistry Therapeutic Use: Hypertension Sales: $ 6.0 Billion Rank:10 Trade Name: Crestor Company: Astrazeneca Technology: Small Molecule Chemistry Therapeutic Use: Cholesterol Lowering Sales: $5.8 Billion Got something to say about this post? Leave a comment...your comments are valuable for improving the posts.